G4-associated human diseases
WebFeb 26, 2024 · Immunoglobulin (Ig)G4 is a unique protein molecule and its role in autoimmune diseases remains elusive and controversial. Accumulating evidence suggests a pathogenic role of IgG4 in rheumatoid arthritis (RA). Rheumatoid factors (RF) in RA can recognize the Fc domains of IgG4 to form RF-IgG4 immune complexes that may activate … WebFeb 25, 2024 · Introduction. Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized condition, with the first report dating two decades ago in Japan in a group of patients with autoimmune pancreatitis in which elevated serum Immunoglobulin G4 (IgG4) levels were identified [].A few years later, it was acknowledged as a systemic condition, …
G4-associated human diseases
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WebDec 1, 2024 · Immunoglobulin G4–related disease (IgG4-RD) is a fibroinflammatory condition that can affect various organs. The kidney is one of the organs most frequently affected and IgG4-related tubulointerstitial nephritis (IgG4-TIN) is the most dominant feature [].However, several radiologically characteristic lesions within the kidney have also been … WebSep 12, 2016 · G-quadruplex (G4) structural motifs have been linked to transcription 1,2, replication 3 and genome instability 4,5 and are implicated in cancer and other diseases …
WebGuanine-quadruplex structures (G4) are unusual nucleic acid conformations formed by guanine-rich DNA and RNA sequences and known to control gene expression mechanisms, from transcription to protein synthesis. So far, a number of molecules that recognize G4 have been developed for potential therapeutic applications in human pathologies, … WebG4s function with other biological structures like R-loop for maintaining cellular and developmental processes. Additionally, targeting G4s as potential biomedical targets …
WebDec 1, 2024 · G-quadruplexes (G4s) regulate a variety of physiological functions related to diseases and life elongation. Therefore, G4 binding ligands, such as potential drugs in gene therapy or molecular probes for biosensing and bioimaging, are receiving extensive attention. ... a G4 formed by the gene present in human tumors and considered as … WebImmunoglobulin G4 (IgG4)-related disease (IgG4-RD) is an immune-mediated condition characterized by infiltration of the involved organs by IgG4-bearing plasma cells. The prevalence of autoimmune diseases, associated with or occurring in patients with human immunodeficiency virus (HIV) infection, has been increasing.
WebJan 30, 2024 · Maizels, N., 2015 G4 ‐ associated human diseases. ... G4-containing RNP granules are identified in both prokaryotes and eukaryotes, but extensive studies have been performed in eukaryotes. We ...
WebApr 29, 2024 · IgG4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory disorder that can affect almost any organ. Common presentations include major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal fibrosis and tubulointerstitial nephritis. The main histopathological features are a dense ... chemistry industry and environmentWebG-quadruplexes and human disease. Features of quadruplex struc-tures that promote genomic instability have been determined. Quadruplexes have been identified as … chemistry indicator examplesflight from nashville to newark njWebFeb 25, 2024 · DNA and RNA can fold into a variety of alternative conformations. In recent years, a particular nucleic acid structure was discussed to play a role in malignant transformation and cancer development. This structure is called a G-quadruplex (G4). G4 structure formation can drive genome instability by creating mutations, deletions and … flight from nashville to philippinesWebOct 8, 2024 · G-quadruplexes (G4s) are involved in some neurological diseases. • Porphyrins are candidate drugs to treat ATR-X syndrome through its G4 binding ability. • … flight from natchez frank g slaughterWebJul 6, 2015 · Coronavirus: Find the latest articles and preprints ... chemistry industryWebThe aim of this article is to draw attention of clinical oncologists to the issue of IgG4-associated diseases group which can mimic cancer condition in various organs in the human body. Therefore, it is necessary to bear them in mind in the differential dia-gnosis of malignant diseases. ... Immunoglobulin G4-Related Disease* / diagnosis chemistry industry association