Fam72a antagonizes ung2

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August undefined, 2024

WebJan 1, 2024 · Download Citation On Jan 1, 2024, Yibin Zeng and others published FAM72A promotes glioma progression by regulating mitophagy through the Pink1/Parkin signaling pathway Find, read and cite all ... WebApr 1, 2007 · UNG2 and SMUG1 are both important for prevention of mutations caused by cytosine deamination, and their functions are non-redundant. In addition, SMUG1 has a major role in removal of hydroxymethyl uracil from oxidized thymines. Furthermore, UNG-proteins and SMUG1 may have important functions in removal of oxidized cytosines, e.g. …

FAM72A promotes glioma progression by regulating

WebFAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Activation-induced cytidine deaminase (AID) catalyses the deamination of deoxycytidines to deoxyuracils within immunoglobulin genes to induce somatic hypermutation and class-switch recombination 1,2. AID-generated deoxyuracils are recognized and processed by ... WebSeveral studies indicated that FAM72A functions by interacting with uracil DNAglycosylase 2 (UNG2), a crucial enzyme in base excision repair (BER), catalyzing the replacement of deoxyuracil (dU ... intresting lamp ideas

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WebDec 23, 2024 · This effect leads to increased genome-wide deoxyuracils in B cells. By antagonizing UNG2, FAM72A therefore increases U•G mispairs that engage mutagenic … WebDec 9, 2024 · FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. FAM72A differentially controls mutation rates by regulating uracil processing at different stages of the cell cycle ... intresting history topics african american

Base excision repair Nature

WebFeb 1, 2024 · FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation Nature 2024. 600(7888):324-328. (PMID: 34819670) Abstract Full Text Link. Sherker A, Chaudhary N, Adam S, Noordermeer SM, Fradet-Turcotte, Durocher D. Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites WebNov 22, 2024 · Family with sequence similarity 72 A (FAM72A) is a pivotal mitosis-promoting factor that is highly expressed in various types of cancer. FAM72A interacts with the uracil-DNA glycosylase UNG2, the enzyme that prevents mutagenesis by eliminating uracil from DNA molecules through cleaving the N-glycosylic bond and initiating the base … new metro 6r4WebThe somatic hypermutation spectrum in B cells from Fam72a−/− mice is opposite to that observed in mice deficient in uracil DNA glycosylase 2 (UNG2)7, which suggests that … intresting information about monkey

"WebAug 1, 2024 · Yet, the mechanisms by which FAM72A regulates UNG2 degradation is an open question. It has been suggested that different genetic loci might exhibit different … " - Fam72a antagonizes ung2

Fam72a antagonizes ung2

WebMar 26, 2024 · FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Title: FAM72A antagonizes UNG2 to promote mutagenic repair during … Web"FAM72A Antagonizes UNG2 to Promote Mutagenic Repair During Antibody Maturation" 11:55 am - 12:00 pm: Discussion. 12:00 pm - 12:20 pm: Sergei Mirkin (Tufts University, United States) "Genomic Weak Links: Mechanisms of Genome Instability Caused by Structure-Prone DNA Repeats" 12:20 pm - 12:30 pm: Discussion. 12:30 pm - 1:30 pm:

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WebSep 26, 2024 · FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination. Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma. WebMar 3, 2024 · FAM72A-D promote the self-renewal of neural progenitor cells. There is accumulating evidence that FAM72 promotes tumorigenicity. However, its effects in lung …

WebJ:326431 Feng Y, et al., FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Nature. 2024 Dec;600(7888):324-328) Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology … WebNov 25, 2024 · So far, the detailed molecular mechanism by which FAM72a antagonizes UNG2 remains to be determined. We are putting efforts into systematically analyzing the molecular interplay between FAM72a with UNG2, and how exactly the binding of FAM72a regulates UNG2 stability and activity. 5:30 p.m. Presenter: Miss Yan LI, MPhil candidate

WebNov 24, 2024 · FAM72A antagonizes UNG2 in the G 1 phase of the cell cycle, leading to reduced processing of the AID-induced dU in Ig genes, which leads to increased G:U … WebOct 26, 2024 · protein FAM72A, LMP1-induced protein, latent membrane protein 1-induced protein. GeneRIFs: Gene References Into Functions. FAM72A antagonizes UNG2 to …

WebJun 11, 2024 · Upregulation of FAM72A coupled with the downregulation of UNG2 in G 1 allows AID-induced U:G mismatches to be preserved until early S-phase, when MutS Homolog2/6 (MSH2/6) binds to the AID-induced mismatch, leading to the generation of single-stranded DNA (ssDNA) exposed by the 5′ → 3′ exonuclease Exo I. UNG2 is re …

WebOur results are consistent with a model in which FAM72A interacts with UNG2 to control its physiological level by triggering its degradation, regulating the level of uracil excision and thus the balance between error-prone and error-free DNA repair. Our findings have potential implications for tumorigenesis, as reduced levels of UNG2 mediated ... intresting mini project in cWebAug 1, 2024 · Yet, the mechanisms by which FAM72A regulates UNG2 degradation is an open question. It has been suggested that different genetic loci might exhibit different susceptibilities to mutagenic BER, ... FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Nature, 600 (2024), pp. 324-328. CrossRef View … new metro apps for windows 8WebIn the present study, we determined a specific FAM72A-UNG2 heterodimer protein interaction using molecular docking and dynamics. In addition, through in silico screening, we identified withaferin B as a molecule that can specifically prevent the FAM72A-UNG2 interaction by blocking its cell signaling pathways. Our results provide an excellent ... intresting math cba ideasWebMar 2, 2024 · Fu et al. find a cell cycle gene, Fam72a, that supports cell proliferation, antagonizes apoptosis, and controls tubulin and Mcl-1 phosphorylation during the G2/M … new metro busesWebDec 21, 2024 · FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. FAM72A differentially controls mutation rates by regulating uracil processing at different stages of the cell cycle ... intresting movie for childrenWebIndeed, FAM72A binds to UNG2, resulting in reduced levels of UNG2 protein in the G1 phase of the cell cycle, coinciding with peak AID activity. FAM72A therefore causes U.G … intresting news in irealandWeb影响因子：9.685. 合作单位：上海交通大学医学院附属第九人民医院. 中科新生命提供的服务内容：靶向色氨酸代谢. # 06. 文献名称：Metrnl alleviates lipid accumulation by modulating mitochondrial homeostasis in diabetic nephropathy. 发表期刊：Diabetes. 影响因子：9.337. 合作单位：贵州 ... intrestingschoology