Dahl salt sensitive rat characteristics

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WebApr 3, 2006 · The Dahl salt-sensitive rat has been used as a model for investigating the characteristics of myocardial hypertrophy, the transition to heart failure, and has been proposed as a model for studying DHF, … WebJul 20, 2024 · The pregnant Dahl salt-sensitive (Dahl S) rat has been described as a spontaneous model of superimposed preeclampsia (8–10). The Dahl S pregnancy is …

Dahl Salt-Sensitive Rats Excrete 25-Hydroxyvitamin D into Urine

WebMar 28, 2024 · Using a Dahl salt-sensitive rat model of HFpEF, the authors delivered cardiosphere-derived cells (CDCs) via intracoronary injection into the microcirculation. After 2 weeks of treatment with CDCs, the hypertensive rats showed improved endothelial-dependent vasodilation, reduced oxidative stress, restored expression of endothelial … WebApr 1, 2024 · Several inbred lines of rats were produced from noninbred stock of Dahl salt-sensitive (S) ... These characteristics are similar to those originally reported by Dahl … pine county obituaries minnesota

Development of Heart Failure in Chronic Hypertensive Dahl Rats

WebThe impact of hypertension on left ventricular (LV) structure, pump function, and heart failure in Dahl salt-sensitive rats is poorly characterized but hypothesized to yield insights into the pathophysiology of heart failure with normal or preserved. The impact of hypertension on left ventricular (LV) structure, pump function, and heart failure ... WebNov 11, 2024 · However, most models available do not reproduce key characteristics of clinical persistent pain. This has limited their ability to accurately predict which new … WebSep 5, 2014 · The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia Ellen E. Gillis,1 Jan M. Williams,1 Michael R. Garrett,1,2 Jennifer N. Mooney,1 and Jennifer M. Sasser1 1Department of Pharmacology and Toxicology,and 2Department of Medicine University of Mississippi Medical Center, Jackson, Mississippi … pine county overdose

A Randomized Trial of Magnesium Oxide and Oral Carbon …

Generation and characteristics of rat models of HFpEF and HFrEF.

WebWe concomitantly assessed genomic regions of rat chromosomes 3 and 7 (RNO3 and. Although genetic determinants protecting against the development of elevated blood pressure (BP) are well investigated, less is known regarding their impact on longevity. We concomitantly assessed genomic regions of rat chromosomes 3 and 7 (RNO3 and WebApr 29, 2024 · Indoxyl sulfate (IS), a protein-bound uremic toxin derived from dietary tryptophan, is shown to accelerate calcification of VSMCs. 34 Oral administration of IS to Dahl salt-sensitive hypertensive rats led to severe aortic calcification. 35 In patients with CKD, serum IS levels were positively correlated with aortic calcification score. 36 ... pine county obituaries mnWebJan 31, 2011 · The DahlS.Z-Leprfa/Leprfa (DS/obese) rat strain was established from a cross between Dahl salt-sensitive rats and Zucker fatty (fa/fa) rats, the latter of which harbor a missense mutation in the ... pine county ordinances

"WebNov 21, 2014 · The Dahl salt-sensitive SS rat is a widely used model of human salt-sensitive forms of hypertension and ... Some of the characteristics of rat lncRNAs appear different than lncRNAs in other ... " - Dahl salt sensitive rat characteristics

Dahl salt sensitive rat characteristics

Rat models of hypertension, cardiac hypertrophy and failure

WebThe Dahl rat is used as a model of hypertension that is "sensitive" to dietary salt (sodium chloride, NaCl). When dietary salt is supplemented in the Dahl rat, the arterial blood pressure of the "salt-sensitive" strain (S) becomes much greater than that of the "salt-resistant" strain (R). WebOct 23, 2024 · The pregnant Dahl salt-sensitive (S) rat is an established preclinical model of superimposed spontaneous preeclampsia charac-terized by exacerbated hypertension, increased urinary protein excretion, and increased fetal demise. Because of the underlying

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WebSome studies have shown that sodium-sensitive individuals share several characteristics. They include increased forearm vascular resistance, decreased venous compliance, … WebThe Dahl salt-sensitive (DSS) rat and the Dahl salt-resistant (DSR) rat, which represents the normotensive control, is one of the inbred rat models that has been widely used to …

WebNov 11, 2024 · In 1962, Dahl et al. selectively bred two contrasting lines of SD rats—outbred salt-sensitive (DS) and salt-resistant (DR) rats for the study of salt-induced … WebHFpEF model: Dahl salt-sensitive (SS) rats were fed a high salt diet (8% NaCl) or a normal salt diet (0.3% NaCl) starting at 7 weeks of age. We obtained echocardiograms at …

WebThe impact of hypertension on left ventricular (LV) structure, pump function, and heart failure in Dahl salt-sensitive rats is poorly characterized but hypothesized to yield insights into the pathophysiology of heart failure with normal or preserved. The impact of hypertension on left ventricular (LV) structure, pump function, and heart failure ... WebApr 27, 2024 · The Dahl salt-sensitive rat model was used to evaluate the therapeutic effects of GZD against hypertension. Results. A total of 112 active ingredients, 222 targets of GZD and 341 hypertension-related targets were obtained. ... Network pharmacology has many same characteristics with TCM, such as the systematic and holistic views. …

WebDahl Salt-sensitive rats 68 Hypertension, eccentric or concen- tric hypertrophy, and systolic and/ or diastolic dysfunction dependen- ing on age-dependent timing of high-salt diet ... mimics most HFpEF characteristics seen in humans, incuding exercise intolerance; well established as a HFpEF model Limitation: no identical genotype in control ...

Webchromosome 13 from the normotensive inbred Brown Norway rat was introgressed into the background of the Dahl/Salt Sensitive rat. Characteristics: Insulin Resistant, … pine county ohioWebSep 9, 1998 · These data support the alpha1 Na,K-ATPase gene as a susceptibility gene for salt-sensitive hypertension in the Dahl S rat model, and provide the basis for the study of the alpha1 Na,K-ATPase locus in human hypertension. ... Rapp JP, Dene H. Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats ... pine county officesWebMay 1, 1996 · Other characteristics of the Brookhaven selectively bred Dahl S rats studied herein are similar to those previously published 13 22 34; their SBP averaged 10 to 20 mm Hg higher than SBP of the Dahl R rat irrespective of dietary salt intake (Fig 1), and the ratio of heart weight to body weight was consistently higher in the Dahl S than R rat fed ... top most used words in englishWebJul 1, 2015 · The mechanisms of the pathogenesis of preeclampsia, a leading cause of maternal morbidity and death worldwide, are poorly understood in part due to a lack of spontaneous animal models of the disease. We hypothesized that the Dahl salt-sensitive (S) rat, a genetic model of hypertension and kidney disease, is a spontaneous model … top most very comfortable pillowsWebThe Dahl salt-sensitive hypertensive rat (Dahl SS) is a well-established rodent model of salt-sensitive hypertension and progressive kidney injury. ... Common among these are … pine county mn government officesWebDec 12, 2016 · The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia. Am J Physiol Regul Integr Comp Physiol 309: R62–R70, ... Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Hypertension 7: 340–349, 1985. top most venomous spidersWebThe Dahl salt-sensitive (DSS) rat is another model of hypertensive CKD and develops hypertension when fed an HSD ( Dahl et al., 1962, 1963 ). In experiments with this strain, low-salt diet generally involves 0.1%–0.4% NaCl, whereas high salt refers to 4%–8% NaCl diet ( De Miguel et al., 2010; Hayakawa et al., 1997; Rapp and Dene, 1985; Yu ... pine county obituaries